Product ID:AZACTAM FOR INJECTION 1000 MG/VIAL
MSDS Date:12/22/1993
FSC:6505
NIIN:01-273-8658
Status Code:A
MSDS Number: CJYQF

Emergency Phone: 208-519-3843

Info Phone: 201-519-2885

Cage: IO660

Telephone: 201-519-2885

Cage: IO660

AZTREONAM

CAS: 78110-38-0

ARGININE

CAS: 74-79-3

RTECS: CF1934200

LD50 LC50 Mixture:ORAL LD50(RAT): 10 G/KG
Routes of Entry: Inhalation:NO Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:SKIN: MAY OCCUR IF PROTECTIVE GLOVES &
CLOTHING ARE NOT WORN. INGESTION: ASTREONAM IS POORLY ABSORBED &
INACTIVATED IN THE GASTROINTESTINAL TRACT. MAY CAUSE DERMATOLOGIC &
HEMATOLOGIC EFFECTS. MAY AFF ECT THE GASTROINTESTINAL TRACT, LIVER
& IMMUNE SYSTEM.
Effects of Overexposure:DIARRHEA, NAUSEA, VOMITING, CRAMPS, RASHES,
ITCHING, FEVER, CHILLS, MUSCLE & JOINT PAIN, DIFFICULTY IN
BREATHING
Medical Cond Aggravated by Exposure:PERSONS WHO ARE ALLERGIC TO
PENICILLINS/CEPHALOSPORINS, GASTROINTESTINAL DISEASES. INDIVIDUALS
W/A HISTORY OF AZTREONAM ALLERIES.

First Aid:INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF
NECESSARY. SKIN: WASH W/PLENTY OF WATER FOR 15 MINS. EYES: FLUSH
W/RUNNING WATER FOR 15 MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES.

Extinguishing Media:WATER
Fire Fighting Procedures:WEAR SELF CONTAINED BREATHING APPARATUS, FLAME
& CHEMICAL RESISTANT CLOTHING, BOOTS & GLOVES. EVACUATE PERSONNEL
TO UPWIND DIRECTION, REMOVE UNNEEDED MATERIAL & COOL CONTAINERS
W/WATER FROM A MAXIMUM DISTANCE.
Unusual Fire/Explosion Hazard:FINE POWDERS ARE CONSIDERED TO BE
COMBUSTIBLE. PROVIDE APPROPRIATE BONDING & GROUNDING PROTECTION TO
CONTROL STATIC CHARGES. POWDER HANDLING EQUIPMENT SUCH AS DUST
COLLECTORS, DRYERS & MILLS MAY REQUI RE ADDITIONAL PROTECTIVE
MEASURES (EXPLOSION VENTING).

Spill Release Procedures:COLLECT TO MINIMIZE DUST GENERATION. USE WET
MOP, DAMP SPONGE/WET/DRY HEPA VACUUM. PLACE COLLECTED MATERIAL INTO
A SUITABLE CONTAINER FOR DISPOSAL. LARGE: USE A NIOSH-APPROVED
DUST/MIST RESPIRATOR. A FTER CLEAN UP, FLUSH W/WATER TO PROCESS
SEWER IF ALLOWED.

Handling and Storage Precautions:CONTAINER REQUIREMENTS: GLASS VIALS.
SHOULD BE STORED AT 59-86F. DON'T EXPOSE TO TEMPERATURES >140F.
Other Precautions:AVOID INHALATION, SKIN/EYE CONTACT W/THIS MATERIAL.
PROTECT FROM MOISTURE. IF EXPOSED TO STRONG LIGHT, THE POWDER MAY
YELLOW SLIGHTLY. AS A PRECAUTION, PERSONNEL WHO HANDLE DRUG
SUBSTANCES SHOULD AVOI D CONTACT W/INGESTION/INHALATION, SKIN & EYE
CONTACT W/THESE SUBSTANCES.

Respiratory Protection:WHEN ENGINEERING CONTROL AREN'T SUFFICIENT TO
CONTROL DUST EXPOSURE, WEAR APPROVED RESPIRATORY PROTECTION. SELF
CONTAINED BREATHING APPARATUS SHOULD BE USED FOR EMERGENCY.
Ventilation:ENCLOSURE OF PROCESSES/LOCAL VENTILATION TO KEEP AIRBORNE
CONCENTRATION BELOW BMS EXPOSURE GUIDELINE OF 1 MG/CUBIC METER
AZTREONAM.
Protective Gloves:IMPERVIOUS, LATEX, NITRILE/RUBBER
Eye Protection:SAFETY GLASSES (ANSI Z87.1).
Other Protective Equipment:PROTECTIVE COVERALLS
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES
BEFORE REUSE.
Supplemental Safety and Health
WASH HANDS AFTER HANDLING COMPOUND & BEFORE EATING, SMOKING, USING
LAVATORY & AT END OF DAY.

Melt/Freeze Pt:=114.C, 237.2F
Vapor Density:>1
Solubility in Water:COMPLETE
Appearance and Odor:WHITE TO YELLOWISH-WHITE CAKED POWDER.

Stability Indicator/Materials to Avoid:YES
Stability Condition to Avoid:AVOID MOISTURE. AZTREONAM IS MOST STABLE
AT PH 6.IS INACTIVATED AT A PH OF LESS THAN 5 & GREATER THAN 8.
Hazardous Decomposition Products:OXIDES OF CARBON, SULFUR & NITROGEN

Waste Disposal Methods:DISPOSE OF IN ACCORDANCE W/LOCAL, STATE &
FEDERAL REGULATIONS.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Transport Information:NOT REGULATED FOR SHIPPING FOR
DOMESTIC/INTERNATIONAL.

State Regulatory Information:THIS MATERIAL SAFETY DATA SHEET IS
INTENDED FOR USE BY PERSONNEL WHO HANDLE THIS MATERIAL AS PART OF
THEIR JOB RESPONSIBILITIES. IT DOES NOT ADDRESS THE THERAPEUTIC USE
OF THIS MATERIAL. INFORMATION C ONCERNING THE THERAPEUTIC USE OF
THIS DRUG SHOULD BE OBTAINED FROM FORMULATED IN PRODUCT PACKAGE
INSERTS & OTHER APPROPRIATE REFERENCES.